Chris Wood's penalty gives Nottingham Forest a 1-0 edge over Aston Villa in their Europa League semi-final first leg, extending their unbeaten run to nine matches.
Nottingham Forest, who finished seventh in the Premier League last season, will replace Palace in the Europa League.
Liverpool will take on LASK, Union Saint-Gilloise and Toulouse in the Europa League group stage while debutants Brighton & Hove Albion will face Ajax Amsterdam and Olympique de Marseille following the draw on Friday.
Aston Villa secured a 2-1 victory at Basel on Thursday, with goals from Evann Guessand and Youri Tielemans keeping their Europa League campaign on a strong footing.
Rennes denied late Europa League equaliser due to little-known rule
In Lille, substitute Olivier Giroud turned the game on its head in the 80th minute.
The first legs of the ties will take place on February 16, with the return match a week later on February 23.
IMAGES from the Europa League matches played on Thursday.
The other semi-final will see an Italian side, Milan or Roma, come up against Bayer Leverkusen or West Ham.
The 24 sides through from the group phase join the eight third-placed finishers in the Champions League in Monday's draw, including Manchester United and Ajax Amsterdam.
Jose Mourinho's side top Group G with a maximum nine points, three clear of second-placed Slavia.
Arsenal sailed through the Europa League group stages, winning five of their six group matches and take on Sporting next, who overcame Denmark's FC Midtjylland in their playoff.
Action from Europa League matches played on Thursday.
Manchester United, winners of the competition in 2017, will have a lot of travelling to do to Eastern Europe after being drawn alongside Kazakhstan side Astana, Serbia's Partizan Belgrade and Dutch side AZ Alkmaar.
The draw also produced a clash between two former European champions with AC Milan facing Serbia's Red Star Belgrade while French league leaders Lille face Ajax Amsterdam in a fascinating tie.
Pogba, who rejoined United from Juventus last year, started all 15 games and scored three times in Europe's second-tier competition to help United lift the trophy for the first time in May.
Brighton secured their second victory of the competition with a comfortable win at Ajax thanks to goals from Ansu Fati and Simon Adingra.
Holders Sevilla maintained their Europa League challenge with a 1-0 win over Rijeka in a winner-takes-all clash on Thursday.
Besiktas's Europa League game at home to Tottenham Hotspur was suspended twice on Thursday after the floodlights failed in each half before the Turkish side won 1-0.
Tottenham Hotspur have been fined 15,000 euros ($18,600) by UEFA after their Europa League game against Partizan Belgrade last month was suspended for several minutes following three separate pitch invasions, the governing body said on Thursday.
In the third-tier Europa Conference League, English Premier League club Leicester City will face Danish side Randers and Scottish club Celtic will take on Norwegian champions Bodo/Glimt in the knockout playoff round.
Manchester United manager Jose Mourinho said Friday's draw for the last 16 of the Europa League against Russian side Rostov has been unkind to his team, the favourites.
While Spurs play Inter Milan at home in Champions League on Wednesday, on Thursday, Arsenal face a long trip to Ukraine to play Vorskla Poltava in the Europa League, needing a victory to consolidate first place in the group.
We want to fight for that title and we are very excited to see the draw, says Ander Herrera
Images from Europa League matches played on Thursday.
IMAGES from the Europa League matches played on Thursday.
Olympique de Marseille were the fall guys on a hectic opening night of Europa League group stage action as German club Eintracht Frankfurt returned from the south of France with a surprise 2-1 victory on Thursday.
Qarabag had chances, Tural Baymarov missing from the penalty spot just before the hour mark and Junior hitting the woodwork, but Spurs stayed in control of the match.
IMAGES from the Europa League matches played on Thursday
Xabi Alonso will take over as Chelsea's new manager, the Premier League club said on Sunday, with the Spaniard signing a four-year deal beginning on July 1.
European champions Chelsea will play Czech side Sparta Prague in the last 32 of the Europa League after the draw was made in Switzerland on Thursday.
Estoril's home Europa League clash with PSV Eindhoven was suspended at halftime on Thursday due to adverse weather and will be finished on Friday, UEFA said.
Striker Luis Suarez scored one goal and missed two second-half penalties as Ajax Amsterdam beat nine-man FC Timisoara 2-1 in Romania on Wednesday to reach the knockout stage of the Europa League.
Sevilla sneaked into the last 32 of the Europa League on Wednesday with a 2-2 draw at home to Borussia Dortmund as the German side failed to translate their devastating domestic form into European success.
Manchester United, Sevilla and Celtic led a parade of clubs with continental pedigree to book the first places in this season's Europa League knockout stage.
Manchester City's Erling Haaland faces Borussia Dortmund and Barcelona's Robert Lewandowski meets Bayern Munich after the Champions League group-stage draw was made on Thursday.
UEFA Cup holders Shakhtar Donetsk thrashed Club Bruges 4-1 away on Thursday when top-level football began experimenting with five-man refereeing teams in the opening Europa League group stage games.
Tottenham Hotspur exposed the weaknesses in Anzhi Makhachkala's star-shorn squad, winning 2-0 in Moscow to maintain their perfect start in the second round of Europa League group stage matches on Thursday.
Tottenham Hotspur could face punishment from European soccer's governing body UEFA after their Europa League game with Partizan Belgrade on Thursday was suspended for several minutes following three separate pitch invasions.
Juventus were astonishingly held to a 3-3 home draw by Lech Poznan as the Europa League group stage kicked off on Thursday while holders Atletico Madrid began the defence of their crown with a 1-0 defeat at Aris Salonika.
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